In today’s era of ubiquitous computing and global online connectivity, e-research is enriching research across a growing range of academic disciplines. Its reach is extending beyond the science and technology fields where it originated, and is now “penetrating the social sciences and humanities, [though] sometimes with differences in accent and label” (Jankowski, 2009). This chapter discusses some of the ways in which humanities researchers are embracing new digital resources, formats and modes of collaborating in ways that further the traditional goals of humanities research, “to better understand ourselves, our history, and our cultural heritage” (Cole, 2007). Topics covered in this chapter include the growing opportunities for collaborative and interdisciplinary approaches, building the information commons for public benefit, and the growing need for strategic investment in research infrastructure to support the humanities.